Studies of crystallization thermodynamics and crystal lattice energies indicate that true racemates have lower entropy, higher enthalpy or higher free energy than enantiomers. Additionally, a relationship inverse to Wallach’s rule was found. Additionally, there are a few cases where a true racemate is a crystal and an enantiomer forms a gel and vice versa. Back to Wallach’s rule, it should be mentioned that the difference in the melting points of more than 46 ☌ is very difficult to explain by the intermolecular H-bonding distinctions between the racemate and enantiomers.
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